DESIGN OF RECEPTOR BINDERS

The overall focus of the project is to build protein carriers that will enter the nervous system after binding to the receptors situated in the blood–brain barrier. We are using Rosetta, a state-of-the-art computational protein modeling software, to construct proteins that will interact with specific targets; these are then characterized experimentally by yeast display and standard biochemical and molecular biology techniques.

The long-term goal is to couple various therapeutics to the designed carriers for improved treatment of the nervous system diseases.